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Fatigue. Disrupted sleep. Mood shifts. Joint tenderness. Brain fog. These aren't separate problems — they are connected expressions of a single underlying biological shift.
What is actually happening in the luteal phase
The premenstrual phase — roughly days 15 to 28 — ends with falling progesterone and oestrogen. As both hormones decline, prostaglandin production rises, oestrogen's anti-inflammatory effects are withdrawn, serotonin falls, and sleep architecture shifts. Each element compounds the others.
The connecting thread is inflammation. Not acute, dramatic inflammation — but cyclical, hormonally-driven inflammatory activity that peaks around menstruation and makes itself felt across every system it touches.
This is a longevity issue, not just a monthly inconvenience
The cyclical inflammatory burden of PMS is interconnected with the chronic low-grade inflammation that drives biological ageing. Women who experience severe PMS show higher baseline inflammatory markers outside the luteal phase. The same cytokines — CRP, IL-6, TNF-α — that peak in the late luteal phase are among the strongest predictors of long-term cardiovascular and cognitive health outcomes. Managing menstrual inflammation consistently is, over decades, a longevity intervention.
What the research shows
Ingredients in AEVUM's Daily Vitals speak directly to the biology of the luteal phase — through complementary mechanisms that together address inflammation, pain, sleep, mood, and energy across the full symptom picture.
Levagen+® (PEA, 375mg)
The most directly evidenced ingredient for premenstrual and menstrual support in the formula.
- For pain: a 2025 clinical study found a single 300mg dose — below our 375mg — produced significant menstrual pain reduction within one to two and a half hours. The mechanism is PEA's ability to calm mast cell activity and reduce the pro-inflammatory mediators driving cramping, joint tenderness, headache, and back pain simultaneously.
- For sleep: a 2021 double-blind, placebo-controlled study demonstrated significant improvements in sleep latency and morning alertness after eight weeks of daily supplementation — at 350mg, below our dose — with no drowsiness effect.
- For nervous system and mood: a 2025 HRV and stress study showed significant improvements in autonomic regulation and perceived stress. Note: this study used 600mg — above our 375mg inclusion. The direction of effect is compelling and consistent with PEA's broader mechanistic profile, but the dose used was higher than Daily Vitals provides.
HydroCurc® (curcumin, 500mg)
Addresses systemic inflammation from a different mechanistic angle.
Hydrocurc® suppresses TNF-α, IL-1β, and IL-6 through NF-κB and COX pathway modulation. The 2022 antioxidant study demonstrated meaningful reductions in systemic oxidative stress markers at 500mg — an exact match to our inclusion.
Together, Levagen+® and HydroCurc® address premenstrual inflammation from complementary angles — supported by Zinc, CoQ10, vitamin C, and vitamin B1 for energy, hormonal balance, and immunity.
Every day of the month
AEVUM's Daily Vitals was not formulated as a PMS supplement. It was formulated as a anti-inflammatory longevity supplement — built around the biology of inflammation, cellular resilience, and foundational health. The premenstrual phase is where that biology is most acutely felt. The formula is designed to support it, every day of the month.
Because the biology doesn't pause between cycles. Neither should the support.
References: Briskey et al. (2025) Levagen+® menstrual pain study; Levagen+® sleep study (2021); Levagen+® HRV and stress study (2025); HydroCurc® antioxidant study (2022); Critchley & Maybin (2020); Franceschi et al. (2018).
