The science behind Daily Vitals

Actives backed by 22 clinical studies

With patented Levagen®+ and HydroCurc®

Longevity and the Inflammation Epidemic

Longevity isn't simply about how long you live — it's about how well you live. Lifespan keeps increasing, but healthspan, the years spent in genuine good health, hasn't kept pace. UK adults now spend up to a quarter of their lives in poor health.

At the root of that gap sits something surprisingly overlooked: chronic inflammation. It's one of the most significant drivers of ageing and poor health — quietly shaping daily energy, recovery, mood, and resilience long before it compounds as a medical diagnosis.

That's why we start there. Supporting inflammation balance means supporting daily vitality now, and healthspan later. Not just adding years, but making the years you have better.

AEVUM Daily Vitals longevity supplement pouch — 90 capsules with Levagen & HydroCurc

'THE INFLAMMATION EPIDEMIC'

1 in 3 people have chronic inflammation.

Mainous et al., 2024, Frontiers in Medicine

We've built Daily Vitals to tackle it at the source.

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How ageing is measured

The Twelve Hallmarks of Ageing

Ageing follows twelve identifiable biological processes, known as the Hallmarks of Ageing.

These hallmarks explain the cellular and molecular changes behind what you actually feel day to day — including your energy, recovery, and resilience. They fall into three broad domains — Damage, Regulation and Communication.

Damage

The Challenge
Over time, the body accumulates molecular damage, causing DNA integrity, vital proteins, and mitochondrial function to decline.

The Reality
Natural cellular repair systems exist, but their efficiency gradually slows down as we age.

The Solution
Supporting these repair processes to keep them effective longer is a foundational goal of target longevity supplementation.

Regulation

The Challenge
Over time, the systems managing metabolism and cellular energy become less precise, and mitochondria produce energy less efficiently.

The Reality
This decline happens gradually, often showing up first as inconsistent energy or slower recovery.

The Solution
Supporting mitochondrial function and metabolic balance is central to keeping this system working well for longer.

Communication

The Challenge
Cells constantly signal each other to coordinate repair and immune response. With age, this signalling breaks down, often driving chronic, low-grade inflammation.

The Reality
Chronic inflammation is one of the most significant, and overlooked, drivers of poor health and ageing. It disrupts how cells coordinate with each other and its impact compounds over time.

The Solution
Supporting inflammation balance restores clearer cell communication, which is why it sits at the centre of our Daily Vitals formula.

How we formulated Daily Vitals

Inflammation is the heart of what we do — but it doesn't operate in isolation. It's interconnected with how you sleep, move, manage stress and make energy. So we built Daily Vitals around the five systems it touches.

Inflammation Balance

The Heart of the Formula

Chronic, low-grade inflammation is one of the most significant drivers of ageing ...

The Heart of the Formula

Chronic, low-grade inflammation — sometimes called "inflammageing" — is one of the most significant, but underestimated, drivers of poor health and early ageing.

Levagen®+ and HydroCurc® sit at the heart of Daily Vitals, chosen for the strength of their clinical evidence. HydroCurc® is delivered via LipiSperse®, boosting curcumin absorption by 3× versus standard forms.

Cellular Resilience

Protection at the Source

Your cells are the smallest unit of your health and need protection from oxidative stress...

Protection at the Source

Your cells are the smallest unit of your health. Cellular resilience depends on how well your body manages oxidative stress and protects DNA, proteins, and mitochondria from damage over time.

Inflammation and oxidative stress feed each other, so protecting cells is part of keeping inflammation in check. Daily Vitals includes Astaxanthin and Resveratrol, studied to support the body's natural antioxidant defences and reduce oxidative damage associated with ageing.

Close-up of two faces side by side, cheek to cheek, illustrating AEVUM's cellular resilience pillar.

Energy Production

Fuel for your Cells

Fatigue is one of the most common, and most frustrating, experiences of ageing...

Fuel for your Cells

Fatigue is one of the most common, and most frustrating, experiences of ageing. Energy production begins at a cellular level and is driven by mitochondrial efficiency, which naturally declines as you age.

Daily Vitals includes CoQ10, the essential compound your mitochondria need to produce energy, alongside Vitamin B and essential micronutrients. Together, they support natural energy production and metabolism at a cellular level.

Friends sharing a meal and laughing at a campsite in a pine forest, illustrating AEVUM's energy production pillar.

Metabolic Health

The Steady Baseline

Metabolic health determines your energy, recovery and body composition...

The Steady Baseline

Metabolic health governs how efficiently you turn food into energy, and it becomes less precise with age. Poor metabolic health shows up as sluggish energy, slow recovery, and stubborn weight.

Daily Vitals includes Chromium, which supports normal macronutrient metabolism and blood glucose maintenance, alongside Alpha Lipoic Acid for its role in cellular energy metabolism.

Smiling woman walking outdoors in knitwear, illustrating AEVUM's metabolic health pillar

Nervous System Regulation

Calm Amid the Noise

Your nervous system governs stress, sleep, and mental clarity...

Calm Amid the Noise

Your nervous system governs how you handle stress, how well you sleep, and how clear-headed you feel. Chronic stress and poor sleep both drive inflammation up; calming the nervous system is one of the most direct ways to bring it back down.

Levagen®+ has been shown in clinical trials to ease everyday anxiety and support faster sleep onset — supported by Zinc and essential micronutrients for normal nervous system function.

Smiling woman holding a baby up, foreheads touching, illustrating AEVUM's nervous system regulation pillar

Supplement Facts

Serving Size (3 Capsules)
Servings Per Pouch (30 Servings)

Ingredient	Per Serving	%NRV*
Levagen®+ Coated Palmitoylethanolamide	375mg	-
Hydrocurc® Coated Turmeric Extract	500mg	-
Resveratrol 98%	100mg	-
Haematococcus Pluviali Powder (Providing 5mg Astaxanthin)	250mg	-
Alpha Lipoic Acid	100mg	-
Co Enzyme Q10 (Ubiquinone)	100mg	-
Vitamin C (Ascorbic Acid)	24mg	30%
Chromium Picolinate	0.012mg	30%
Vitamin B1 (Thiamine)	0.33mg	30%
Zinc Bisglycinate (Core Chelate®)	3mg	30%

The LipiSperse® delivery technology used Levagen®+ and HydroCurc® contains Oat Lecithin, meaning Daily Vitals is not suitable for individuals with gluten sensitivity or intolerance.

Trusted by leading experts

Collaborating with the best minds across longevity, health & wellness

Dr. Tom Maden-Wilkinson, Ph.D

Scientific Director and Associate Professor, Sheffield Hallam University

Michal Cohen-Sagi

Functional Medicine Coach and Longevity CEO, Vidavii

Andrew Varnham, D.C

MChiro, Doctor of Chiropractic, Evolve Chiropractic Clinic

"As a researcher in muscle physiology and healthy ageing, I look for supplements built on real evidence rather than hype. AEVUM Daily Vitals stands out for grounding its formulation in ingredient-level clinical research rather than vague wellness claims; the kind of rigor and quality I'd want to see more of in this space."

Dr. Tom Maden-Wilkinson, Ph.D

Scientific Director and Associate Professor, Sheffield Hallam University

"After nearly two decades in wellness, I've learned that more isn't always better. Many people take 10, 15 or even 20 supplements a day without knowing whether the doses are right or how everything works together. What attracted me to Daily Vitals was the thought behind the formulation - carefully selected, evidence-based ingredients, in forms the body can actually use. Simplicity is what makes consistency possible, and Daily Vitals provides this strong daily foundation."

Michal Cohen-Sagi

Functional Medicine Coach and Longevity CEO, Vidavii

“After years of working with people recovering from injuries and managing the physical demands of everyday life, I’ve seen how important it is to move well. Our joints and mobility shape how we train, work and live, yet we often only think about them when there’s a problem. What attracted me to Daily Vitals is its proactive approach — carefully selected, evidence-based ingredients designed to support joint health and mobility. Longevity isn’t just about living longer, but moving well and enjoying life along the way.”

Andrew Varnham, D.C

MChiro, Doctor of Chiropractic, Evolve Chiropractic Clinic

Levagen+ palm fruit source used in AEVUM Daily Vitals

375mg

Patented

Levagen®+ (PEA)

Turmeric root, the source of HydroCurc® curcumin

500mg

Patented

HydroCurc® (Curcumin)

Close-up illustration representing coenzyme Q10 (ubiquinone)

100mg

CoQ10

100mg

Alpha Lipoic Acid

Red microalgae, the natural source of astaxanthin

5mg

Astaxanthin (2%)

Japanese knotweed leaves, the natural source of resveratrol

100mg

Resveratrol (98%)

3mg (30% NRV)

Zinc Bisglycinate

12mcg (30% NRV)

Chromium Picolinate

330mcg (30% NRV)

Vitamin B1 (Thiamine)

24mg (30% NRV)

Vitamin C

Faded background image of four people looking out at the coast, background for AEVUM's ingredients section

375mg

Patented

Levagen®+ (PEA)

Source: Sustainably sourced palm kernels — providing a rich source of palmitoylethanolamide.

Mechanism:

Modulates TRPV1 receptors and the endocannabinoid system, reducing neurological inflammation and pain sensitisation, without psychoactive effects. Uses LipiSperse® for 1.75× standard absorption.

Primary Benefit:

Reduced joint discomfort and improved sleep onset within 8 weeks; lower anxiety markers within 2 weeks.

500mg

Patented

HydroCurc® (Curcumin)

Source: Curcumin — the primary active compound in turmeric.

Mechanism:

Inhibits inflammatory pathways (including NF-κB signalling) and reduces oxidative stress. Standard curcumin is very poorly absorbed; LipiSperse® delivers 3× standard absorption.

Primary Benefit:

Reduced inflammatory markers and 26% increase in BDNF within 6 weeks; eased joint discomfort within 2 weeks.

100mg

CoQ10

Source: Ubiquinone — a compound essential to mitochondrial energy production, naturally declining with age.

Mechanism:

Supports the electron transport chain that generates cellular energy, while acting as an antioxidant that helps lower inflammatory markers.

Primary Benefit:

Reduced TNF-α, IL-6, and CRP over 8 weeks; supports steadier cellular energy.

100mg

Alpha Lipoic Acid

Source: Naturally occurring — an antioxidant compound involved in mitochondrial energy metabolism.

Mechanism:

Supports cellular energy production and helps regenerate other antioxidants at a cellular level.

Primary Benefit:

Included for its foundational role in cellular energy metabolism and antioxidant recycling.

5mg

Astaxanthin (2%)

Source: Haematococcus pluvialis — a naturally occurring carotenoid antioxidant from algae.

Mechanism:

A potent antioxidant that helps neutralise oxidative stress and supports a healthy inflammatory and immune response.

Primary Benefit:

Reduced oxidative stress; studied for its role in recovery and performance.

100mg

Resveratrol (98%)

Source: Japanese knotweed extract — providing an exceptionally concentrated source of trans-resveratrol.

Mechanism:

Activates SIRT1 longevity pathways and reduces key inflammatory markers, supporting long-term cellular resilience.

Primary Benefit:

Lower TNF-α and CRP; improved insulin levels, even below the 100mg dose.

3mg (30% NRV)

Zinc Bisglycinate

Source: Naturally occurring — an essential trace mineral in bisglycinate form for optimal absorption.

Mechanism:

A cofactor for enzymes involved in immune cell function and protein synthesis.

Primary Benefit:

Contributes to normal cognitive function, protection of cells from oxidative stress, normal immune function and normal DNA synthesis.

12mcg (30% NRV)

Chromium Picolinate

Source: Naturally occurring — an essential trace mineral in picolinate form for optimal absorption.

Mechanism:

Supports insulin signalling pathways for normal macronutrient metabolism.

Primary Benefit:

Contributes to normal macronutrient metabolism and the maintenance of normal blood glucose concentrations.

330mcg (30% NRV)

Vitamin B1 (Thiamine)

Source: Naturally occurring — an essential B-vitamin found in whole grains, seeds and legumes.

Mechanism:

A cofactor in carbohydrate metabolism, converting food into usable cellular energy and supporting nerve signalling.

Primary Benefit:

Contributes to normal energy-yielding metabolism, normal nervous system function, normal psychological function, and normal heart function.

24mg (30% NRV)

Vitamin C

Source: Naturally occurring — an essential water-soluble vitamin found in citrus fruits, berries and vegetables.

Mechanism:

A key antioxidant that protects cells from oxidative stress and supports normal immune cell function.

Primary Benefit:

Contributes to protection of cells from oxidative stress, normal energy-yielding metabolism, normal immune function, and reduction of tiredness and fatigue.

The evidence behind the formula

Six of our ten actives are backed by 22 dose-matched, human clinical trials — see exactly what was tested, and what it found. The remaining four micronutrients are dosed at 30% NRV to provide essential daily top-ups.

HydroCurc® Curcumin 500mg

6 Trials

What the trials showed
All 6 trials used exactly 500mg — the same dose as in AEVUM. Results included up to 3× better absorption than regular curcumin, reduced muscle soreness after training, a 26% rise in BDNF (a marker of brain health), and eased joint pain within 2 weeks.

What you might notice
Less stiffness the day after a hard workout. Some people feel a bit sharper mentally after a few weeks of consistent use. Everyday joint comfort may improve within 2 weeks.

Levagen®+ PEA 375mg

8 Trials

What the trials showed
8 trials used 300–350mg — at or below AEVUM's 375mg dose. Results included 1.75× better absorption than standard PEA, falling asleep around 19 minutes (3×) faster than placebo, eased joint stiffness and improved function over 8 weeks, and reduced everyday anxiety within 2 weeks.

What you might notice
Falling asleep a little easier, and waking up sharper. Less stiffness in the joints after a few weeks of consistent use. A steadier, calmer mood day to day.

CoQ10 100mg

3 Trials

What the trials showed
All three trials or subgroups used CoQ10 at or close to AEVUM's 100mg dose. Results included lower TNF-α and IL-6 (key inflammatory markers), reduced CRP, and reduced inflammation and oxidative stress over 8 weeks.

What you might notice
Steadier energy through the day — particularly if you battle the 3 o'clock slump. Builds gradually over several weeks as cellular levels replenish.

Resveratrol 100mg

2 Trials

What the trials showed
Both trials used resveratrol at or below AEVUM's 100mg dose. Results included lower TNF-α and CRP, and improved insulin levels even at doses under 100mg.

What you might notice
A background, cumulative active rather than a felt-in-the-moment one — supporting your body's long-term inflammatory and metabolic resilience.

Alpha Lipoic Acid 100mg

1 Trials

What the trials showed
Evidence at AEVUM's 100mg dose is more limited than our other actives — most ALA research on blood sugar uses much higher doses (300–600mg), which we don't claim to match. At our dose, ALA is included for its established role in cellular energy metabolism and antioxidant recycling.

What you might notice
A supporting role rather than a standalone effect — works alongside CoQ10 to support how your cells produce energy.

Astaxanthin 5mg

2 Trials

What the trials showed
Both countable trials used astaxanthin at or close to AEVUM's 5mg dose. Results included reduced oxidative stress and support for a healthy inflammatory and immune response, alongside studied effects on recovery and performance in competitive athletes.

What you might notice
This one works quietly in the background — steadier recovery and resilience over weeks and months, rather than something you'll feel change day to day.

Clinical Evidence

HydroCurc® Curcumin

500mg · Patented Ingredient · LipiSperse® Delivery

6 Human Trials

✓ Dose Match

DB-RCT Trial Design

Key Findings

3x Better Absorption
Than standard curcumin via LipiSperse® delivery technology
BDNF +26%
Rise in essential brain longevity protein after 6 weeks
Joint pain eased in 2 weeks
Significant VAS score reduction vs placebo, measurable from day 3

Study Details

Duration Acute to 6-week trials

Population Healthy adults, active males, adults with joint pain

Method Double-blind, placebo-controlled RCT

Wearable Tracking

Recovery score · HRV trend · Post-workout soreness

Clinical Evidence

Levagen®+

375mg · Patented Ingredient · LipiSperse® Delivery

8 Human Trials

✓ Dose Match

DB-RCT Trial Design

Key Findings

1.75× Better Absorption — vs standard PEA, peaking at 45 minutes (28 healthy adults)
Fall Asleep ~3× Faster — ~19 minutes quicker sleep onset over 8 weeks (103 adults)
Eases Joint Stiffness — improvement in pain, stiffness and function over 8 weeks (adults with knee osteoarthritis)

Study Details

Duration Acute to 8-week trials

Population Healthy adults, adults with sleep disturbance, adults with knee osteoarthritis

Method Double-blind, placebo-controlled RCT

Wearable Tracking

Sleep latency & score · HRV & readiness · Recovery score

Clinical Evidence

CoQ10

100mg · From Ubiquinone

3 Human Trials

✓ Dose Match

RCT Trial Design

Key Findings

Lowers TNF-α and IL-6 — key inflammatory markers, effect confirmed in lower-dose subgroups
Reduces CRP — at the exact 100mg dose used in Daily Vitals
Reduces Inflammation & Oxidative Stress — over 8 weeks

Study Details

Duration 8–48 weeks

Population Adults (mixed healthy/clinical)

Method Meta-analyses & double-blind RCT

Wearable Tracking

HRV & readiness

Clinical Evidence

Resveratrol

100mg · From Japanese Knotweed Extract

2 Human Trials

✓ Dose Match

RCT Trial Design

Key Findings

Lowers TNF-α and CRP — across 17 RCTs, 736 subjects
Improves Insulin Levels — in the below-100mg subgroup

Study Details

Duration Varies (meta-analyses)

Population Mixed adults, including those with blood-sugar concerns

Method Meta-analyses of RCTs

Wearable Tracking

HRV trend · Glucose trend (CGM-adjacent)

Clinical Evidence

Alpha Lipoic Acid

100mg · Mechanism-supported

1 Human Trials

✓ Dose Match

RCT Trial Design

Key Findings

Supports Cellular Energy — meta-analyses note its role in energy metabolism and antioxidant recycling at a cellular level

Study Details

Duration Varies (meta-analyses)

Population Mixed adults

Method Meta-analyses of RCTs

Wearable Tracking

Readiness score

Clinical Evidence

Astaxanthin

5mg · From Haematococcus Pluvialis

2 Human Trials

✓ Dose Match

RCT Trial Design

Key Findings

Reduces Oxidative Stress — supports a healthy inflammatory and immune response (CVD-relevant populations)
Studied in Professional Athletes — effects on substrate metabolism and recovery in competitive cyclists

Study Details

Duration Acute to review-level evidence

Population CVD-relevant adults, competitive cyclists

Method RCT

Wearable Tracking

HRV trend · Recovery & performance

Woman smiling outdoors, background image for AEVUM's science table

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Women's Health

When Menopause Turns Up the Inflammatory Volume

The menopause conversation is usually about oestrogen. But a parallel story is emerging: the transition is also an inflammatory event, with chronic inflammation sitting underneath much of what women actually report.

Looking for answers?

Here's everything you might be wondering about inflammation, longevity, and Daily Vitals. Want to speak to the team instead? Just click below.

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Inflammation & Longevity

Why is inflammation the focus?

Most longevity supplements treat symptoms in isolation — sleep, energy, joints — without addressing the source of the problem.

Chronic inflammation is one of the most significant, yet overlooked, drivers of poor health, illness and ageing. Research suggests as many as 1 in 3 adults live with chronic inflammation. Daily Vitals puts inflammation balance at the heart of the formula because it's central to both daily vitality and longevity.

What is longevity and why is it important?

Longevity is the practice of closing the gap between lifespan (how long you live) and healthspan (how well you live).

In the UK, many of us are living longer, but not always living well — ONS data shows UK adults now spend up to a quarter of their lives in poor health.

Longevity exists not simply to add years to your life, but to ensure vitality throughout them — so you feel capable, energised, and well enough to do whatever you want, for however long you want to do it.

Daily Vitals

What makes Daily Vitals different?

Daily Vitals is the UK's first longevity supplement built with clinically studied ingredients to target one of the most significant, yet overlooked, drivers of poor health and ageing — chronic inflammation.

Founded following our Co-Founder Niamh's own experience with brain inflammation, AEVUM exists to raise awareness about the role chronic inflammation plays in both your immediate and long-term health, and to provide a simple, sustainable, science-backed solution.

How do I take Daily Vitals?

We recommend taking all 3 Daily Vitals capsules with your first meal of the day.

Pairing it with a balanced plate - including protein, healthy fats and fibre - can help keep you fuelled and may support optimal nutrient absorption.

Shipping & Returns

Where do you ship to?

We currently ship within the UK and Northern Ireland only.

All orders include free tracked 48-hour delivery.

What is your money-back guarantee?

We believe in what we've built, and we'd never want apprehension to hold someone back on their journey to health.

With that in mind, we offer a 90-day money-back guarantee — if you commit to trying Daily Vitals for three months and still don't feel a difference, we'll refund you. See our policies page for more information.

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Partner with AEVUM to offer your clients and patients longevity support built on patented, clinically studied actives. Dosed to match the evidence — and built to champion inflammation balance as the root of long-term health.

The science behind Daily Vitals

Longevity and the Inflammation Epidemic

1 in 3 people have chronic inflammation.

The Twelve Hallmarks of Ageing

Damage

Regulation

Communication

How we formulated Daily Vitals

The Heart of the Formula

Protection at the Source

Fuel for your Cells

The Steady Baseline

Calm Amid the Noise

Supplement Facts

Trusted by leading experts

Ten ingredients. One clinically-backed formula.

The evidence behind the formula

HydroCurc® Curcumin

Levagen®+

CoQ10

Resveratrol

Alpha Lipoic Acid

Astaxanthin

Explore AEVUM's Longevity Library

Looking for answers?

Inflammation & Longevity

Daily Vitals

Shipping & Returns

Shape the future of longevity with us.